Single or single-ish people: Don't let the name scare you off—this game is great for situationship-ers as well because it builds intimacy without being overtly sexual.
Bedroom Twister is best played as a strip game or in the nude! Of course, you can avoid this fate if you have a "defuse" card, or you can outrun danger altogether by using your cards to skip turns and go at other players.
It is worth noting that several games are excellent for just two players.
Several good variations exist, and in parts of Canada one of them is played under the name in French: Deux Cents.
As a fan of Cyanide and Happiness, I enjoyed this game right out of the gate.
The person whose card the judge picks wins the round.